ICORD will focus its research efforts around six integrated themes that aim to minimize the effects of spinal cord injury to prevent paralysis, maximize recove ry and quality of life for people living with spinal cord injury, and promote re generation of the spinal cord to restore full physical function. The themes have been established to create a circular flow of action.

Theme 1: SCI Registry

The flow is initiated in Theme 1 through the development of a multidisciplinary, comprehensive SCI Patient Registry to accurately assess and track SCI damage, functional impairment, and recovery.

The remaining themes are directed to the discovery and translation of improved f unctional outcomes for the SCI community. The research will come full circle, as future experimental interventions and developments will be evaluated using the outcome measures established by Theme 1.

Theme 2: Molecular Screen

Themes 2, 3 and 4 are focused on basic science discoveries. Theme 2 will identify which genes and proteins change after SCI or as a result of therapeutic SCI intervention. This comprehensive molecular screen will identify the most appropriate molecules to target for therapies.

Theme 3: New Models of SCI

In Theme 3, ICORD engineers, spine surgeons and neuroscientists will develop ne w animal models of SCI that more accurately simulate the majority of human spinal cord injuries, namely injuries that occur within the enclosed vertebral column .

Theme 4: Combinational Therapies

Theme 4 will determine which combination of experimental therapies are the most likely candidates for translation into clinical interventions.

Theme 5: Rehabilitation Strategies

Theme 5 will pursue evidence-based rehabilitation strategies to define and validate best practices.

Theme 6: Assistive Technology

Theme 6 will focus on the development of innovative assistive devices and new technologies to facilitate independence and quality of life for people with SCI.